Re: PMID: 12640080: Surgery for PD: no reliable evidence

["Robert A. Fink, M. D." <rafink@xxxxxxxxxxxxx>]

Date sent:              Sun, 30 Mar 2003 12:55:15 -0500
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From:                   janet paterson <janet313@xxxxxxxxxxx>
Subject:                PMID: 12640080: Surgery for PD: no reliable evidence
To:                     PARKINSN@xxxxxxxxxxxxxxxxxxxx

> Surgery for Parkinson's disease: lack of reliable clinical trial
> evidence.
>
> There has been a striking resurgence of interest in surgery for
> Parkinson's disease (PD) with new targets identified and new
> procedures developed. This systematic review identified over 500
> studies of surgery for PD published since 1990, including over 10,000
> patients. However, the authors were unable to assess the value of PD
> surgery reliably because only seven randomised trials were identified
> including just 196 patients. Studies of surgery for PD have generally
> been of poor quality with too few patients, too short follow up,
> inappropriate choice of outcome measures, and lack of control groups.
> Much larger, randomised, controlled trials are needed to assess the
> longer term effects of surgery on patient rated quality of life and
> cost effectiveness.
>
> J Neurol Neurosurg Psychiatry 2003 Apr;74(4):519-21
> Stowe RL, Wheatley K, Clarke CE, et al.
> University of Birmingham, Birmingham, UK
> PMID: 12640080
>

I generally agree with this article.

Best,

Bob

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Robert A. Fink, M. D., F.A.C.S., P. C.
2500 Milvia Street  Suite 222
Berkeley, California  94704-2636
Telephone:  510-849-2555   FAX:  510-849-2557
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"Ex Tristitia Virtus"

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