PMID: 12740572: Levodopa-induced dyskinesia reduced in monkey

[janet paterson <janet313@xxxxxxxxxxx>]

hi all

'normalizing receptor function'
'correct side effects' -
this kind of new news warms the cockles of my heart!

if levodopa minimizes my pd symptoms
and if i didn't get side effects from taking levodopa
how would i even know i had pd?

and here's more proof
as if we need it
that managing pd longterm is a matter of finer and finer tuning -
put that sledgehammer away!

janet

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Attenuation of levodopa-induced dyskinesia by normalizing dopamine D(3)
receptor function.

In monkeys rendered parkinsonian with
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), expression of the
dopamine D(3) receptor was decreased.

However, levodopa-induced dyskinesia (LID), similar to the debilitating and
pharmaco-resistant involuntary movements elicited after long-term treatment
with levodopa in patients with Parkinson disease (PD), was associated with
overexpression of this receptor.

Administration of a D(3) receptor-selective partial agonist strongly
attenuated levodopa-induced dyskinesia, but left unaffected the therapeutic
effect of levodopa.

In contrast, attenuation of dyskinesia by D(3) receptor antagonists was
accompanied by the reappearance of PD-like symptoms.

These results indicated that the D(3) receptor participated in both
dyskinesia and the therapeutic action of levodopa, and that partial
agonists may normalize D(3) receptor function and correct side effects of
levodopa therapy in patients with PD.

Nat Med 2003 May 12;
Bezard E, Ferry S, Mach U, et al
Basal Gang, Laboratoire de Neurophysiologie, 33076 Bordeaux, France.
PMID: 12740572
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janet paterson: an akinetic rigid subtype, albeit primarily perky, parky
pd: 56-41-37 cd: 56-44-43 tel: 613-256-8340 email: janet313@xxxxxxxxxxx
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