Re: Sinemet

["William A. Parrette" <wap@xxxxxxx>]

Hi all,

        On Mon, 24 Jan 2000, the digest contained:

> ...
> Date:    Mon, 24 Jan 2000 11:01:27 -0500
> From:    "Hawkins, Darwin" <Darwin.Hawkins@xxxxxxxxxxxxxxxxxx>
> Subject: Re: Sinemet
>
> Would taking one 25/100 every 3 hours be closer to approximating the desired
> effect of one 50/200 every 6 hours? Seems to me it would smooth things out.
> ...

        First, let me say (as has been said before) everybody's physi-
     ology is different and different medications rarely have the same
     effect on two different people.  This is especially true with PW-
     Ps and Sinemet.

        That being said:

        25 mg. Carbidopa/100 mg. Levodopa x 8 (every 3 hours) =
                              200 mg. Carbidopa/800 mg. Levodopa a day

        50 mg. Carbidopa/200 mg. Levodopa x 4 (every 6 hours) =
                              200 mg. Carbidopa/800 mg. Levodopa a day

        And, although apparently the same levels of each ingredient is
     being used, the regular Sinemet delivery would have  "spikes"  in
     its  delivery-graph  and effectiveness.  Where the CR (controlled
     release) version's delivery-graph would be smoother.  In  theory,
     the  delivery of the CR is spread out more evenly over its effec-
     tive period which results in a more even control of the  tremors;
     where  the non-CR version would result in more control soon after
     the dose was taken and less control toward the end of its  effec-
     tive period.

        If I remember correctly, the delivery-graphs for both products
     are available at:

                         

        But, then again, all us PWPs is different ... :-)

Bill--
  ...who heard that minds are like parachutes -- they function only when open.
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