Re: PMID: 10746597: APOE and the risk of PD with or without dementia in a population-based study

[Murray Charters <Murray_Charters@xxxxxxxxx>]

On 15 Apr 2000, at 23:44, Hans van der Genugten wrote:

> Neurology 2000 Mar 28;54(6):1272-6
>
> APOE and the risk of PD with or without dementia in a population-based
> study.
>
> Harhangi BS, de Rijk MC, van Duijn CM, Van Broeckhoven C, Hofman A, Breteler
> MM
>
> Department of Epidemiology & Biostatistics, Erasmus Medical Center
> Rotterdam,
> The Netherlands.
>
> OBJECTIVE:
> To study the association between APOE genotype and PD with or without
> dementia.
>
> METHODS:
> The study formed part of the Rotterdam Study, a prospective,
> population-based cohort study on the frequency, etiology, and prognosis of
> chronic diseases. The cohort examined for PD consisted of 6,969
> independently
> living or institutionalized inhabitants from a suburb of Rotterdam, the
> Netherlands, aged 55 years or older. All participants were screened at
> baseline (1990 to 1993) and at follow-up (1993 to 1994) for symptoms of
> parkinsonism by study physicians; screen positives received a diagnostic
> workup by a neurologist.
>
> RESULTS: APOE genotyping was available for 107 PD patients (26 with and 81
> without dementia) and 4,805 non-PD control subjects. The presence of at
> least one epsilon2 allele significantly increased the risk of PD (OR = 1.7;
> 95% CI, 1.0 to 2.8). When we looked separately for demented and nondemented
> PD patients as compared with nonparkinsonian controls, APOE did not appear
> to be associated with PD without dementia, but both the epsilon2 and the
> epsilon4 allele increased the risk of PD with dementia (OR = 5.6; 95% CI,
> 2.0 to 15.2 and OR = 3.6; 95% CI, 1.3 to 9.9). The risk of dementia for
> epsilon4 allele carriers was not significantly different for persons with or
> without PD. However, the epsilon2 allele strongly increased the risk of
> dementia in patients with PD (interaction p < 0.007).
>
> CONCLUSIONS: In the elderly the APOE-epsilon2 allele increases the risk of
> PD and, in particular, the risk of PD with dementia.


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