Re: Bad reaction to sinemet, info please

[Jorge A Romero MD <romeroja@xxxxxxx>]

It is difficult to understamnd why you had such a reaction to such a small dose 
of Sinemet.

Under normal circumstances, unless you take enough Carbidopa (the 25 of 
25/100), most of the
levodopa will be metabolized before it even gets into the brain - this may 
cause side effects.

Some PWP taking small doses of carbidopa/levodopa find that they have fewer 
side effects when they
actually increase the dose somewhat to make sure they are taking enough 
carbidopa - usually at least
75 mg per day.  An alternative is to use Lodosyn (pure carbidopa) supplement 
which is now available
by prescription also.

Jorge Romero, MD

----- Original Message -----
From: plmaddux <plmaddux@xxxxxxxxxxx>
To: <PARKINSN@xxxxxxxxxxxxxxxxxxxx>
Sent: Tuesday, April 25, 2000 6:26 PM
Subject: Bad reaction to sinemet, info please


> I just took my first dose of sinemet and am having a bad reaction, I have
> tremor as only symptom, took 1/2 of 25/100 witha light meal at 5pm, two
> hours later my tremor in 4 times as violent as it has ever been, just talked
> to doctor, he was no help, just said that sometimes sinemet does not help
> tremor. what is going on here, i never heard of sinemet making sympoms worse
> rather than better.
>
> Lanier Maddux   64,4
>
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