PMID: 10928577: Anxiety and depressive disorders preceding PD: a case-control study.

[janet paterson <janet313@xxxxxxxxxxx>]

Anxiety disorders and depressive disorders preceding Parkinson's disease: a
case-control study.

We studied the association between preceding psychiatric disorders and
Parkinson's disease (PD) using a case-control design.

We used the medical records-linkage system of the Rochester Epidemiology
Project to identify 196 subjects who developed PD in Olmsted County,
Minnesota, during the years 1976-1995.

Each case was matched by age (+/-1 yr) and sex to a general population
control.

We reviewed the complete medical records of cases and control subjects to
detect preceding psychiatric disorders.

The frequency of psychiatric disorders was higher in cases than in control
subjects; the odds ratio was
2.2 for anxiety disorders (95% confidence interval [95% CI] = 1.4-3.4; p =
0.0003), 1.9 for depressive disorders (95% CI = 1.1-3.2; p = 0.02), and 2.4
for both anxiety disorders and depressive disorders occurring in the same
individual (95% CI = 1.2-4.8; p = 0.02).

When we restricted analyses to disorders present 5 years or more before the
onset of motor symptoms of PD, the association with depressive disorders
lost statistical significance.

However, the association with anxiety disorders remained significant for
disorders present 5, 10, or 20 years before onset of motor symptoms.

Our results suggest that anxiety disorders and depressive disorders are
associated with PD and that the causative process or the risk factors
underlying PD are present many years before the appearance of motor symptoms.


Mov Disord 2000 Jul;15(4):669-77
Shiba M, Bower JH, Maraganore DM, McDonnell SK,
Peterson BJ, Ahlskog JE, Schaid DJ, Rocca WA
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
PMID: 10928577

janet paterson
53 now / 44 dx cd / 43 onset cd / 41 dx pd / 37 onset pd
tel: 613 256 8340 url: ";
email: janet313@xxxxxxxxxxx smail: POBox 171 Almonte Ontario K0A 1A0 Canada