Re: Ibuprofen v Parkinson's

[Genene Hill <geneneh@xxxxxxxxxx>]

Charles,

Can you tell us what specifically was studied and the results of the study?



on 10/8/00 8:33 AM,  Charles Williams at Charles.Williams1@xxxxxxxxxxxxxx
wrote:

> I have heard this theory too, in UK. In fact I took part in research on
> scans that is based on the idea that MSA and PD are associated with
> inflammation, which may contribute to progression. Documentation mentioned
> the possibility of anti-inflammatory drugs like aspirin being used for
> treatment.
> 
> -----Original Message-----
> From: William P. Taggart <billt@xxxxxxxx>
> To: PARKINSN@xxxxxxxxxxxxxxxxxxxx <PARKINSN@xxxxxxxxxxxxxxxxxxxx>
> Date: 08 October 2000 11:36
> Subject: Ibuprofen v Parkinson's
> 
> 
> Ibuprofen may reduce the risk of Parkinson's and Alzheimer's     <<...>>
> 
> 
> Although non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen
> have been found to reduce the risk of Alzheimer's disease (AD), the
> underlying mechanisms of action are unknown. However, Casper and colleagues
> have recently found that NSAIDs protect neurones from glutamate toxicity in
> vitro - glutamate toxicity has been implicated in AD, Parkinson's disease
> (PD), and other diseases.
> Aspirin, acetaminophen, and ibuprofen were all found to attenuate the
> reduction in dopamine uptake caused by glutamate on cultured primary rat
> embryonic neurones taken from the mesencephalon area of the brain,
> indicating preservation of neuronal integrity. Furthermore, ibuprofen 100µm
> protected both dopaminergic neurones and neurones generally, against
> glutamate toxicity. In addition, of the drugs tested, only ibuprofen
> increased the relative number of dopaminergic neurons - by 47%.
> The authors concluded that NSAIDs deserve further consideration as
> neuroprotective agents in PD.
> Source: Casper D et al. Neuroscience Letters 2000;289(3):201-204. Updated
> September 2000.
>