Re: pd and cd and suicide

[Jemima Harrison <jem@xxxxxxxxxxxxxxxxxxxxxxxxxx>]

>
> i've understood that serotonin shortage is implicated in both cd and pd
> is that your understanding too?


I understand PWP can suffer from up to 40 per cent depletion in serotonin -
a clear reason for depression.  That said, serotonin is not purely linked to
mood and there is increasing evidence that it plays a role in movement, too.
There's a team in Manchester, UK, working on - and having success with -
drugs which inhibit/excite serotonin to treat PD and dyskinesias. It was
this group that proved that the sub-thalamic nucleus/globus pallidus pathway
was glutaminergic - which led directly to the introduction of amantadine,
the first non-dopaminergic drug for PD.

Jemima