Re: pd and cd and suicide

[Carole Hercun <grinchcsh@xxxxxxxxx>]

Fascinating-it just gets more and more complex, doesn't it?
We have so much to learn re: the mysteries of the brain.
                     Carole

--- Jemima Harrison <jem@xxxxxxxxxxxxxxxxxxxxxxxxxx> wrote:
> >
> > i've understood that serotonin shortage is implicated
> in both cd and pd
> > is that your understanding too?
>
>
> I understand PWP can suffer from up to 40 per cent
> depletion in serotonin -
> a clear reason for depression.  That said, serotonin is
> not purely linked to
> mood and there is increasing evidence that it plays a
> role in movement, too.
> There's a team in Manchester, UK, working on - and having
> success with -
> drugs which inhibit/excite serotonin to treat PD and
> dyskinesias. It was
> this group that proved that the sub-thalamic
> nucleus/globus pallidus pathway
> was glutaminergic - which led directly to the
> introduction of amantadine,
> the first non-dopaminergic drug for PD.
>
> Jemima


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