PMID: Neuroprotective effect of vitamin E

[Raymond Strand <strandra@xxxxxxxxxxxxx>]

hello list:

Neuroprotective effect of vitamin E has been investigated before.
It does not across the blood/brain barrier.
Vitamin C is reportedly good too.

Ray
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 Brain Res 2001 Feb 16;892(1):211-217

Neuroprotective effect of vitamin E on the early model of Parkinson's
disease in
rat: behavioral and histochemical evidence(1).

Roghani M, Behzadi G

Department of Physiology, School of Medicine, P.O. Box 19835-181, Shaheed
Beheshti University of Medical Sciences, Tehran, Iran

[Record supplied by publisher]

There is strong evidence that oxidative stress participates in the etiology of
Parkinson's disease (PD). We designed this study to investigate the
neuroprotective effect of vitamin E in the early model of PD. For this purpose,
unilateral intrastriatal 6-hydroxydopamine (12.5 ?g/5 ?l) lesioned rats were
pretreated intramuscularly with D-alpha-tocopheryl acid succinate (24 I.U./kg,
i.m.) 1 h before and three times per week for 1 month post-surgery. Apomorphine-
and amphetamine-induced rotational behavior was measured postlesion fortnightly.
A parallel tyrosine hydroxylase immunoreactivity and wheat germ agglutinin-horse
radish peroxidase (WGA-HRP) tract-tracing study was performed to evaluate the
vitamin E pretreatment efficacy. Tyrosine hydroxylase-immunohistochemical
analyses showed a reduction of 18% in ipsilateral substantia nigra pars compacta
(SNC) cell number of the vitamin E-pretreated lesioned (L+E) group comparing
with contralateral side. The cell number dropped to 53% in the lesioned (L+V)
group. In addition, retrograde-labeled neurons in ipsilateral SNC were reduced
by up to 30% in the L+E group and 65% in the L+V group. Behavioral tests
revealed that there are 74% and 68% reductions in contraversive and ipsiversive
rotations in the L+E group, respectively, as compared with the L+V group.
Therefore repeated intramuscular administration of vitamin E exerts a rapid
protective effect on the nigrostriatal dopaminergic neurons in the early
unilateral model of PD.

PMID: 11172767

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                                 Ray Strand
                             Prairie Sky Design
 -----------------(   on  the Edge of the Prairie Abyss  )---------------
                          when  the  sky  is  clear
                            the ground is visible

                     49/dx PD 2 yrs/40? onset/retired