Re: Low protein diet

[Mark Robbins <cmrci@xxxxxxxxxx>]

Dear Bob,
As I recall, Eldepryl is a MAO-B inhibitor and therefore would not have
a problem with cheese or other substances with tyramine. You would be
exactly correct if the patient was using a MAO-A inhibitor.
Documentation for this can be found at 

Quote from the above web site:
Originally developed as a "psychic energizer" selegiline, also known as
L-deprenyl or Eldepryl, appeared to be an irreversible inhibitor of the
MAO-B enzyme. The MAO-B enzyme constitutes the main degrading pathway
for dopamine, the transmitter which is deficient in the brain in
Parkinson's disease  An important advantage of selegiline compared with
other MAO inhibitors was its lack of the "cheese effect". This effect is
caused by the uptake of a food constituent, tyramine, which is present
in high concentrations in cheese and Chianti wine, and causes the
sudden, marked elevation of blood pressure in patients treated with
other, previously used MAO inhibitors.

Mark

-----Original Message-----
From: Parkinson's Information Exchange Network
[mailto:PARKINSN@xxxxxxxxxxxxxxxxxxxx] On Behalf Of Robert A. Fink, M.
D.
Sent: Friday, December 28, 2001 10:36 AM
To: PARKINSN@xxxxxxxxxxxxxxxxxxxx
Subject: Re: Low protein diet

Date sent:              Fri, 28 Dec 2001 04:20:54 +0000
Send reply to:          Parkinson's Information Exchange Network
<PARKINSN@xxxxxxxxxxxxxxxxxxxx>
From:                   Charles Countryman <c.countryman@xxxxxxx>
Subject:                Low protein diet
To:                     PARKINSN@xxxxxxxxxxxxxxxxxxxx

> various cheeses

If you are on MAO inhibitors (like Eldepryl), the cheese could be the
culprit.  Not the protein itself.

Best,

Bob


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Robert A. Fink, M. D., F.A.C.S., P. C.
2500 Milvia Street  Suite 222
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Telephone:  510-849-2555   FAX:  510-849-2557
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