Re: Debate about the

[Brightline <brightline@xxxxxxxxxxxxxxx>]

Hi!
    I remember reading sometime ago which amounted to someting like this:

    It is known that dopamine producing cells are stimulated to produce more
dopamine-lioke substances from sinemet.  This may work forseveral years,
however, it looses effect after that and produces only harmful side effects.
Later on, by a study from Australia (?) indicated that the reason for the
lack of effect after some time is that the neorons are dead an gone leaving
an empty spacee. But, as far as I know sinemet does not cause the death of
neurons; if the recent news confirms that sinemet is causing the death of
neurons, I am not aware of that.  I caught in the TV news (CNN Headlinr
Newws at 10.30 PM (9.30 PM ET on 31May2002) a glimpse of such bad effect of
sinemet; I got curious and watched the 11.PM (10 PM ET) version of the same
news; however, this happened to be another edition, in which they have
omitted thi part of the news.
    Raj
    brightline@xxxxxxxxxxxxxxx
*************
----- Original Message -----
From: "Kathleen Cochran" <CochranK@xxxxxxx>
To: <PARKINSN@xxxxxxxxxxxxxxxxxxxx>
Sent: Sunday, June 02, 2002 12:10 PM
Subject: Re: Debate about the


> In a message dated 6/2/2002 3:58:10 AM, rhysmorris@xxxxxxxxxxxxxx writes:
>
> <<  "adds to the debate over whether the current use
>
> of dopamine in the treatment of Parkinson's could make things worse in the
>
> long run,"
>
>  >>
> Rhys,
>
> My neuro said there is some evidence that dopamine, while effective
> initially, in the long run may have some destructive effects. I don't know
> the specifics but, like you, would like to know more.
>
> I found it interesting to read fairly recently about the patient who
received
> an experimental treatment and, a year later, still showed significant
> amelioration of symptoms even though his dopamine levels, which had risen
> with treatment, had declined to their original levels. This suggests to me
> that dopamine depletion is only part of a complex interaction and focusing
on
> dopamine alone is not going to get us where we need to go.
>
> Regards,
> Kathleen
>
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