Re: Kinase inhibitor

[Brightline <brightline@xxxxxxxxxxxxxxx>]

Hi! Charlotte:
    You are right on with reference to the overall concept.  This 'conflict
of  interest' could be one of the reasons why some times, sinemet has been
attributed to aggravating melanoma.  But however, this has not been
coraborated by followup studies.
    Different type of cells undergo slightly different modes of apoptosis.
Therefore, I think there is still hope for specifically inhibiting apoptosis
in one cell type and promoting apoptosis in another cell type.
    The following article gives a good summary of the situation:
    "Cell death: different mechanisms produce different outcomes" by Nicole
Johnston. The Scientist, Vol. 16, No. 3, June 24, 2002.
    You can access this article via 'net without subscription.

    Raj
brightline@xxxxxxxxxxxxxxx

********************
----- Original Message -----
From: "Charlotte Mancuso" <mancann@xxxxxxxx>
To: <PARKINSN@xxxxxxxxxxxxxxxxxxxx>
Sent: Saturday, August 24, 2002 1:40 PM
Subject: Re: Kinase inhibitor


> Hi,
>
> I think, please everyone check me on this, it goes something like
> this--cells, in our case neurons die; cells are supposed to die and be
> replenished or we would have too many.  But sometimes things go wrong and
> apoptosis, the cell's programming for cell "suicide" or death, occurs
> when it shouldn't, and no one knows why. It is a BIG question in
> research.  For cancer I suppose they would like to provoke apoptosis in
> the tumor; in our case, to slow or stop it.
>
> As I said at the start, this is my recollection of the very basic
> concept, and it needs checking.
>
> Charlotte
>
> On Sat, 24 Aug 2002 11:58:24 -0400 Bob Allison <ballison@xxxxxxxx>
> writes:
> > Does anybody have any info on the experimental use of kinase
> > inhibitors to
> > slow PD?   There is a clinical trial for new PDers and I may enlist.
> >  I
> > looked in PubMed but all of the relevant articles are way over my
> > head.
> > This class of drugs seems to revolve around the research on
> > apoptosis(?)
> > which seems to be a key line of research in the battle against
> > cancer.  Any
> > signs would be appreciated.
> >
> > PS  Raj   I did figure out how to access ALL med journals on pubmed;
> > thanks
> > for your tips.
> >
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