Re: Mirapex, Requip and Tasmar

["Ronald F. Vetter" <rfvetter@xxxxxxxxxxxxxxxx>]

>From: Bruce Anderson <bbanderson@xxxxxxxxxxxxxxxx>

>I have an appointment on Monday afternoon with a real movement disorders
>specialist my neuro has encouraged me to see.  My main symptoms are causing
>me more and more problems and I am going to bring up the topic of changing
>medications. I currently take one 25/100 Sinement and four .25mg Permax 4
>times a day (although I skip the evening ones about 1/3 the time). I have
no
>tremor or diskenesia,.  My greatest problem is bradykensia, balance, just
>walking in general, rigidity you might call it.  It's getting worse. When
>the meds have worn off I literally have to bounce off the walls to get
>around the house.

this indicates that more duration from adding tolcapone - or a 5th 25/100
Sinemet so that you would be taking it just before the last one's effect is
insufficient - would be recommended

I have fallen a number of times and have messed up both
>my knees.
>
>I am also finding my hands are getting heavier when typing, makng that more
>difficult.
>
>My question is  -  would any of these three new drugs be likely to help
>these problems?  Or are hey memore likely to help other symptoms like
>tremor.

I would judge that you are undermedicated to the extent that you are
apparently running 'out' before the next is taken.

Ronald Vetter  1936, dz PD 1984, carbidopa/levodopa, Mirapex, selegiline
rfvetter@xxxxxxxxxxxxxxxx     Ridgecrest, California

----------
>
>I tried for a week taking  half the dosage of the Permax and Sinement twice
>as often, but it  seemed to make my mobility worse. I have never tried
>Sinement CR, and I ha been taking Amantadine 200mg/day and   Eldepryil
>10mg/day  for the past 3 years but stopped taking them about 6 weeks ago.
>
>I wold like to have some idea of what to expect from him in the way of med
>changes, if any.
>
>Thanks for any help anyone would care to offer.
>
>Bruce Anderson (52,3+)
>Schooleys Mtn, NJ
>bbanderson@xxxxxxxxxxxxxxxx
>