Re: NEWS: Nose drops may improve treatment of neuro-degener

[Alastair Wyse <wyse@xxxxxxxxxxxxxxxxxx>]

   Hi Joao

> Hi Alastair ,
>
> Alastair Wyse wrote:
>
> >  1) If PD is a lack of dopamine in the brain ???
> >  2) If drugs can be delivered via the nose avoiding the blood/brain
> > barrier ???
> >  It follows that the best treatement for  PD is snorting dopamine !!
> >  I dont have a source of dopamine . But I tried snorting my L-dopa
> > first thing this morning . I was hoping for a faster response .
> >
> > NO such luck . In fact it was far less than the normal swallowing .
>
> How did you proceed to inhale the levodopa ? Was it in a solid state ? 
> Perhaps it
> should be vaporized first to make it possible the snorting way . Or else 
> powered to
> a very fine state ....
>
 I just emptied the powder out of my Madopar 125 cap and snorted  it
. I actually used the contents of two caps to allow for losses .
  Certainly the experiment could have been inproved  . As you suggest
I could have disolved the caps contents and either sprayed it or nose
dropped it up my nose . This would have been a refinement I would
have tried if the first crude trial had showed any positive results .
  Theoretically even if you do not accept the idea that snorting
avoids the blood/brain barrier you should be getting a lot of
delivery improvement by avoiding losses due to gut and liver .
Assuming the drug is disolving in the nasal mucus and passing into
the blood on the way to the brain it should avoid a lot of the
chemicals used by the body to neutralise the drug ( In the case of
L-dopa , com T) .
 I dont understand how this delivery system works and I suspect no
one else does as there is no explanation .  It may only work for
certain types of drugs .
 I note that it works for IGF-1 . This drug is used to stimulate
nerve regrowth and it is one of the drugs I intend to try this winter
on a trip to Mexico (medical drugs are available over the counter
without prescription ) , to see if it improves PD . I have got to
wait till winter as I can no longer stand hot weather with PD .
  I still think snorting dopamine should be tried . Snorting nicotine
in the form of snuff has been a traditional way of enhansing the
brain's dopamine level as has snorting cocaine  .
  I find in my case that boosting the dopamine level produces merely
a feeling of light headeness ( ones first cigarette ) but no
improvement in PD symptoms . L-dopa did nothing for me for 9 months .
I was only after a week of 12 caps a day that I got any real benefit
it unfortunately also increased my dyskinesia . Since then the
beneficial effects of L-dopa are getting shorter and the dyskinesia
worse . For these reasons I have serious doubts about PD being a
shortage of dopamine .  L-dopa does a lot more than boost the
dopamine level . It seems to me that in my case these are the major
therapeutic effects .
  Since PD theory is so inadequate to explain what I have experienced
I feel one should have a stab at less conventional theories and
practices to see if they work . It seems that conventional therapy
leads to the the conventional result ( progressive worsening of
symptoms ) . Snorting the contents of my Madopar cap was a small
experiment  . I have much bigger ones lined up .
>
>
     peace
          Alastair     ( wyse@xxxxxxxxxxxxx )