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Ritalin info


the April 4, 98 issue of Science News contains an article on
Ritalin,page213.

methylphenidate is the active ingredient and there are two enantiomers -
half of each- in the drug.

testing to determine activity of the separated enantiomers, d-threo and
l=ADthreo, separately using PET scans showed that the d-threo enantiomer seek=
s
the basal ganglia where the drug's therapeutic effect. usage to treat
attention deficit-hyperactivity disorder was the focus.

it was suggested that formulating with only the d-thrreo enantiomer in the
med might reduce side effects.

methyphenidate acts by retarding the re-uptake of dopamine according to the
review article.

Ronald Vetter  1936, dz PD 1984, carbidopa/levodopa, Mirapex, selegiline
rfvetter@xxxxxxxxxxxxxxxx     Ridgecrest, California



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