Re: Sinemet"kick-in" tip

[Brian Collins <bjc@xxxxxxxxxxxxxxx>]

On Fri 28 May, Brennan, Terry wrote:
> Brian,
>
> I'd like to hear more about your last sentence, "You may not suffer any
> noticeable effects, but this may be because you are on the 'learner slopes'
> of PD, and damage may still be occuring, and will show up in later stages of
> PD." In particular, I'd like to hear a description of the 'learner slope'
> and where someone might go from there and the second item is regarding the
> 'damage'. Are we refering to our old friend the free radical?
>
> Terry Brennan
>
>
>
Hello Terry, You were the only one to pick up my rather provocative statement.
I did'nt really expect to get away un-noticed. So; to answer your questions-
All of my comments are consistent with my philosophy of what is going on
when we take Levodopa. (Have you read my paper on  'A Model to describe the
Effect of Levodopa........" See the following URL

<>

It has always seemed crazy to me that when a  PWP is first diagnosed, he
should be put on  (Typically) 100mg oor even 200mg tablet dosages,  when
a couple of weeke ago, he didn't even need any extra at all. To absorb
the unwanted part of the big tablet, The Dopamine system has to swing into
action, and shut down a number of (good) dopamine cells to counterract the
excess from the tablet. I believe ( and I have seem a few hints that I am
not alone) that the effect of these swings to off then back to on imposes
considerable stress on the cells, some of which die.
 It follows that my preferred method of coping is only to take the minimum
amount of Dopamine, which is indicated on the referrenced chart.

The wide difference between the two ways of taking the tablets means that
you can take virtually ant size of tablet and get a positive result. This
is what I call the learner slopes of treatment. They last to around 7 or
so from start of treatment. after which things get more difficult,
producing what the ignorant call 'unexpected  fluctuations in response to
medication, and I call an inbred inability to embrace the concept  that
you don't have to take whole, integer, doses of levodopa tablet. - There
are such dosages as .7  of a tablet.

You ask about Free Radicals - frankly, I don't think much of them as a cause
of PD. Maybe they contribute a little to cell stress, as do upwards of 20
other factors. It is the sum of these (hypothetical ) factors which I
believe causes  PD.
Regards,

--
Brian Collins  <bjc@xxxxxxxxxxxxxxx>