Re: question re comt inhibitors

[Carole Hercun <grinchcsh@xxxxxxxxx>]

Hi janet: Intriguing difference in the mechanism of
action, no? I thought I understood the blood-brain
barrier business, but now I, too, am confused. Would
somebody in the audience please clarify?
                  Carole H.

--- janet paterson <janet313@xxxxxxxxxxx> wrote:
> hi all
>
> after reviewing the pmid abstracts on comt
> inhibitors
> i started mulling
>
> i hadn't realized
> that tolcapone crosses the blood brain barrier
> while entacapone doesn't
>
> if the work that this class of med does
> [saving lovely levodopa from arterial ambush by
> those vile venous comt conspirators]
> is done in the bloodstream prior to arrival at the
> brain station
> why would either of them have to cross the blood
> brain barrier?
> anyway?
>
> just a late nite thote about cone pone
>
> janet
>
> janet paterson
> 52 now / 41 dx / 37 onset
> 613 256 8340 po box 171 almonte ontario canada K0A
> 1A0
> a new voice:
> <>
> <janet313@xxxxxxxxxxx>
>


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