Re: question re comt inhibitors

[Carole Hercun <grinchcsh@xxxxxxxxx>]

Whoa- Crystal balls, guinea p--s, hi-jackings, and
Bermuda Triangles? All this action in my poor depleted
AM brain. Time to join you and eat my grits.   Carole

--- janet paterson <janet313@xxxxxxxxxxx> wrote:
> At 08:52 1999/10/23 EDT, you wrote:
> >Janet,
> >On behalf of those maligned Catachol O Methyl
> Transferases,
> >I afta say tat they are just doing their job,
> Ma'am.  Why have
> >one act within the BBB?  In the normal brain,
> Monoamine oxidase
> >and COMT are responsible for cleaning up left over
> dopamine.
> >However, in the PD brain there is no excess....
>
> aha!
> so the comt conspirators have nuttin to do
> just hangin around behind the BBB
> [blood-brain-barrier] commuter station
> rumblin for trumble in our
> poor-pd-put-upon-processors
>
> >The idea behind inhibitors as PD therapy is
> preserving dopamine for
> >use by the brain not capable of producing adequate
> supplies of its
> >own.  Dopamine in the synapse is sorta where "the
> rubber meets the
> >road. "  Avoiding breakdown in the extra BBB area
> would be helpful
> >too, but not as helpful...
>
> i guess
> i always got the impression that the 'extra BBB
> area'
> [=all the parts of our body-bags which are not
> inside the brain-bag - ouch]
> was where the work had to be done
> and
> that some outrageous figure like 80% [don't quote
> me]
> of levodopa is ambushed by comt conspirators while
> in transit
> between the DD [duo-denum] station and the BBB
> [blood-brain-barrier] station
>
> sort of a commuter-bus-hi-jacking in miniature
>
> when i talked with my dalk
> about the possibility and desirability
> of my starting on tasmar/tolcapone many moons ago
> i got the impression that the
> lovely levodopa passenger arrival rates at the BBB
> station
> would be not only greater in number but also
> 'smoother' -
> there would not be 'holes' left in the bus schedule
> due to buses disappearing into the comt equivalent
> of the
> bermuda triangle
>
> but hey
> i've been wrong before
> and i'll be wrong again - that's a promise
>
> >I predict that entacapone will be the "weaker " of
> the two drugs.
>
> aha!
> two
> dusting off our crystal balls are we?
> and
> hah!
> i'll bet those of us [one newfie comes to mind]
> who suffered from tasmar's side effects
> will cheer loud and long
>
> i also noticed that
> tolcapone is not taken at the same time as levodopa
> while entacapone is
>
> i wonder what other differences between tolcapone
> and entacapone
> could have a bearing on us the guinea pigs?
>
>
> janet
> who has some cereal correspondence to attend to
> and apparently is in the perfect frame of mind to
> tackle it
>
> janet paterson
> 52 now / 41 dx / 37 onset
> 613 256 8340 po box 171 almonte ontario canada K0A
> 1A0
> a new voice:
> <>
> <janet313@xxxxxxxxxxx>
>


=====

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