Re: question re comt inhibitors

[janet paterson <janet313@xxxxxxxxxxx>]

At 23:38 1999/10/23 +0100, you wrote:
>I wish someone coould make an authoritative statement on the ability of
>Tolcapone and/or Entacapone to cross the blood/brain barrier. Janet has heard
>that Tolcapone does, and Entacapone doesn't, while I am quite clear that I
>was told some time ago (When Tolcapone was originally approved) that
>Tolcapone cannot cross the barrier. I remember it well, because I asked my
>friendly local neurologist how Tolcapone worked, and he confessed with
>some embarrassment that he didn't know, because of the above inability to
>cross into the brain. It may also be relevant that Tolcapone was withdrawn
>because it caused liver failure (in a  small number of people). i.e. in
>the body, not the brain.
>
>--
>Brian Collins  <bjc@xxxxxxxxxxxxxxx>
>

hi brian

i posted 9 abstracts on the subject a few days ago
they formed the basis for my comments

janet

janet paterson
52 now / 41 dx / 37 onset
613 256 8340 po box 171 almonte ontario canada K0A 1A0
a new voice: <>
<janet313@xxxxxxxxxxx>