Re: Sinemet and food

["J.R. Bruman" <jrbruman@xxxxxxxxxx>]

Camilla, I'm unsure of this, but I think the advice against food applies
only to regular Sinemet and not to Sinemet CR. I read somewhere that the
half-lives respectively are 90 min and 3 hr. Maybe one of our pharmacists
can clarify.
Cheers,
Joe


J. R. Bruman (818) 789-3694
3527 Cody Road
Sherman Oaks CA 91403


On Mon, 8 Jul 1996, Camilla Flintermann wrote:

> Friends--not to "beat a dead horse", but I have to confess to some
> confusion about the Sinemet/food connection.  We have had very persuasive
> info from a number of people to the effect that Sinemet taken with food
> loses much of its value by the time it gets out of the stomach. It sounds
> so reasonable--then I notice that Peter's new RX bottle of Sin.CR 50/200
> has a label shouting "TAKE WITH FOOD" !  So I called the pharmacist and
> asked about it, telling him what I had learned here. His reply was that this
> is the instruction from the manufacturer and the FDA requires them to so label
> it.  He stated that the "package insert" is taken right from the PDR, which
> is the info supplied by the manufacturer. He could not explain it further.
> Now I wonder, are we correct in believing there's a problem, and that we need
> to wait 30-60 min. after taking it before eating? Is there something about
> the CR form that makes a difference in this way?  (He could not find ANY
> info in the PDR about regular Sin. and food, only the CR form.) We would very
> much appreciate    clarification on this issue, which is something Peter
> and others have to decide about many times a day! Thanks for any help you
> can give.(We did discuss the need for food if one is nauseated.)
> Camilla Flintermann,CG for Peter,78/7Oxford,OH
> pcflinte@xxxxxxxxxxxxxxxxx
>