Re: SINAMET DOSES

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Re: SINAMET DOSES

Subject: Re: SINAMET DOSES
From: JHSTARR <JHSTARR@xxxxxxxxxxxxxx>
Date: Sat, 12 Apr 1997 21:20:20 -0400
Reply-to: JHSTARR@xxxxxxxxxxxxxx
Sender: Parkinson's Information Exchange <PARKINSN@xxxxxxxxxxxxxxxxxxxx>

Sinamet is a combination of Carbadopa and L-Dopa.(25/100 = 25mg
Carbadopa and 100mg L-Dopa). At L-Dopa doses above 600mg per day the
chances of dyskinetic side effects greatly increase. The current
thinking is to keep the L-Dopa dose as low as possible by combining it
with dopamine agonists and/or Eldepryl. Soon there will be a new class
of drugs available called COMT inhibitors (Tolcapone), which will also
aid in keeping the L-Dopa dose low.             Jerry Starr  RPh.

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