Re: Models for PD -Reply

[Joao Paulo Carvalho <joaocarv@xxxxxxxxxxxxxxxx>]

Brian Collins wrote:
>
> and there is a quantity left over. I imagine this left-over amount as
> rather like a river in flood, and over flowing its banks, spreading into
> areas and stimulating muscles which we do not want to be stimulated. There
> is another feature of a flooding river which is relevant: a river usually
> floods at the same points, and covers the same areas of land, just as in
> PD, when the dyskinesias occur, it is the same muscles which start acting
> up. ( I am referring to my personal experience here: Other people will no
> doubt find different muscles are affected, because (to use the flooded
> river analogy, the topography of the surrounding landscape is different, so
> different muscles are triggered, but again always the same for that person.
>  Your mention of the 'Synaptic cleft' as a return path for dopamine
> interested me , because I wondered if this might be our 'flooded river' -
> the place where an excess of dopamine has to go, and in the process fires
> off these semi-random tremors.
>

Hi Brian,

In your river model you forgot to mention that our body must have too
some sort of "dams" and other systems for "flood control" .... what
would you say abou it ? What happens if they do not operate as they
should to avoid the "floods" ?   :-)

REgards,
   +----| Joao Paulo de Carvalho   |------ +
   |         joaocarv@xxxxxxxxxxxxxxxx     |
   +--------| Salvador-Bahia-Brazil |------+