Parkinsn's Archive Treasures Doctors, students, patients and caregivers find current Parkinson's information such as the Algorithm, Caregivers Handbook, and talks by respected Movement Disorder Specialists.
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NEWS: Tolcapone Improves On-Off Periods in PD [April 1997]
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April 17, 1997 Clinical results presented at the American Academy of Neurology annual meeting in Boston indicate that tolcapone (Tasmar, Roche) is effective in patients with Parkinson's disease suffering from on-off periods. Tolcapone is the most potent and selective inhibitor of COMT, the enzyme that metabolizes levodopa peripherally, discovered to date. In a double-blind, placebo-controlled trial of 215 patients, Adler et al. found that tolcapone reduced off periods by 30-37%, even as daily levodopa requirements were reduced by 36-46%. Tolcapone was well tolerated, with only 3-5% of patients withdrawing from the study because of adverse effects. Study results are similar to those reported in the Jan. Neurology (1997; 48: 81-7). <http://www.pharminfo.com/pubs/pnn/pnn9.html#8> ----------------------------------------------------------------------- ----------janet-paterson---50-9---paterson@xxxxxxxxxxxxxxxxxxxxxxxxxxx
Parkinsn's Archive Treasures Doctors, students, patients and caregivers find current Parkinson's information such as the Algorithm, Caregivers Handbook, and talks by respected Movement Disorder Specialists.
Mail converted by MHonArc
2.6.10