PMID: 9331903: Neural transplantation hope Sweden 200/6 1997

[janet paterson <paterson@xxxxxx>]

-----------------------------------------------------------------------
Neural transplantation: a hope for patients with Parkinson's disease.
-----------------------------------------------------------------------

More than 200 patients with Parkinson's disease (PD) have received
intrastriatal grafts of human embryonic mesencephalic tissue.

The clinical trials demonstrate that grafted dopamine (DA) neurons can
survive in the human parkinsonian brain and reinnervate part of the host
striatum.

Long-term graft survival and function, at least up to 6 years after
transplantation, is possible in PD despite a progressive degeneration of
the patient's own DA neurons.

A majority of patients with surviving grafts show long-term improvement of
therapeutic value, but symptomatic relief is incomplete.

Current research strategies to develop neural transplantation as a
treatment for PD include:

(i) to increase DA neuron survival and density and extent of the
dopaminergic reinnervation in the striatum;

(ii) to implant DA neurons in denervated regions outside the
caudate-putamen and to reconstruct the nigrostriatal pathway; and

(iii) to find other sources of cells suitable for grafting.


Neuroreport 1997 Sep 29;8(14):III-X
Lindvall O
Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.
PMID: 9331903, MUID: 97472955
-----------------------------------------------------------------------

janet paterson/50/9/sinemet/selegiline/prozac/paterson@xxxxxx/bermuda