Parkinsn's Archive Treasures Doctors, students, patients and caregivers find current Parkinson's information such as the Algorithm, Caregivers Handbook, and talks by respected Movement Disorder Specialists.
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Re: Drug Holiday? (PD Med Problems)
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Joy Graham wrote: > On a related topic: There are many theories about putting PD medications > into the system. One school believes that a constant supply of levodopa > such as you get in the slow release (Sinemet CR or Madopar HBS) is more > beneficial in the long run than the stops and starts of regular dosing. Joy, I have found that the actual data of blood plasma concentration of the early testing of CR Sinemet compared to regular Sinemet (November 1989 Neurology 39 (suppl 2) page 25 article: "Pharmacokinetics and bioavailability of SinemetCR: A summary of hunman studies" Yeh, August, Bush, Lasseter, Musson, Schwartz, smith and Titus) does not indicate that CR gives a "constant supply of levodopa". My plots and comments on the information can be found: http://www.ridgecrest.ca.us/~rfvetter/levoplas.html If you or anyone has information about Madopar HBS, I would like to acquire such. There is a great variability in the data re plasma concentration using CR. I have no data on any of the Madopar medications. -- Ron Vetter 1936, '84 PD dz paradise is feeling good, not a place to go rfvetter@xxxxxxxxxxxxxxxx http://www.ridgecrest.ca.us/~rfvetter
Parkinsn's Archive Treasures Doctors, students, patients and caregivers find current Parkinson's information such as the Algorithm, Caregivers Handbook, and talks by respected Movement Disorder Specialists.
Mail converted by MHonArc
2.6.10