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Skin problems antagonized by agonists?
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I've lurked here for several years, occasionally popping in with a comment or question. Here I am with another of the latter... Vitals: Age 42 Diagnosed at 38, however bradykenesia was evident for several years before that, especially on my right (dominant) side. Even several years before that, say at about age 32/33 I had noticed that when I yawned very deeply (i.e. mouth stretched open all the way) that if my right arm was not anchored or resting against something, that it would tremble. I also have suffered from various skin maladies since I was a teenager; I was told my skin would clear up by the time I was 25, then 30, then 35, etc... In late 1994 I was started on pergolide (Permax), after amantadine, bromocriptine, and selegiline had been tried without symptomatic relief. Permax did provide symptomatic relief, letting me type once again; but it was tricky managing the dose to get the relief without the nasty side-effects (for me - feeling nauseated/yucky and depressed). But as the dose of Permax was titrated up, my skin began to get worse; pimples and infected hair follicles whose severity seemed directly tied to the Permax level. Neither my neurologist nor my dermatologist thought that made any sense; and I can't be sure the correlation was real and not just coincidental. Recently this year, I finally gave up on the Permax, the functionality improvements weren't worth the yucky depression. I'm now taking Sinemet CR and ropinirole (Requip), I've got close to the same functionality, only slight yuckies with the morning dose, and no depression. So what am I writing about, well, as I titrated up the ropinirole, I started blossoming with the pimples and infected hair follicles again (after my skin being relatively calm during the Sinemet CR only period between the Permax and the Requip). Again, I can't prove a connection, it could be coincidence again. So my question is, has anyone else had anything similar happen to them? Also, these eruptions take forever to heal, although they eventually do; I have other "symptoms" that indicate poor blood flow at the skin (due to autonomic nerve disfunction?), which I guess could both contribute to the outbreaks (although I can't be sure how) and contribute to the slow healing. Does any of this ring a bell with anyone, or am I alone on this one? John Stafford -- http://pw2.netcom.com/~johnws/index.html -- johnws@xxxxxxxxxxxxx ................... Si fallatis officium, quaestor infinitius eat se quicquam scire de factis vestris.
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