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Re: apoptosis
My wife has PD for 20 years and now she is hallucinating and
confused very badly. I heard about ZOFRAN, that is being research for the
promlem. Can anyone share about this drug for this purpose.
thanks.
Abraham Freund
recon@xxxxxxxxxxxxxxxxxxxxxxxxxx
On Sun, 3 Dec 1995, J.R. Bruman wrote:
> I agree with your remarks about levodopa possibly enhancing undesirable
> free radical production in the brain. Somewhat more ominous, however, is
> the possibility that dopamine itself can be harmful, in excess. The
> current therapy which delivers dopamine to deficient areas in the
> substantia nigra seems crude at best and difficult to regulate, and the
> research on apoptosis seems to indicate that excess dopamine is one of
> the stimuli that cause dopaminergic neurons to shut down (atrophy? or
> die?). If true, this hypothesis supports the notion that levodopa therapy,
> while known to be effective, should be approached cautiously and frugally.
> For most of us this presents a tough choice, impossible to confirm, and
> we can only hope for the day when those neurons can be restored and
> preserved.
> Cheers, Joe
>
>
> J. R. Bruman (818) 789-3694
> 3527 Cody Road
> Sherman Oaks CA 91403
>
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