[no subject]

[Barbara Patterson <patterso@xxxxxxxxxxxxxxxxxxx>]

---------- Forwarded message ----------
Date: Sun, 31 Dec 1995 09:38:26 -0600 (CST)
From: Steven E. Mayer <Mayers@xxxxxxxxxxxxxxxxxxxxx>
To: patterso@xxxxxxxxxxxxxxxxxxx
>
>>Margaret,
>>After being on Sinemet for the last 10 years with increasing dosages,
>>I hit a condition where I experienced over medication and the dreaded
>>dyskinesia or under medication with paralyzing bradykinesia.
>>I have been ramping up on the Permax and decreasing the Sinemet over the
>>last 3 weeks.  The transition has been a terrible experience. I expect the
>>process will take about three month before I am comfortable again.
>>Check with your neurodoctor about Permax.
>>
>>Jon Stedman  <JDStedman@xxxxxxx>
>>
>>PS:  What is the meaning of the "bid" and "tid" on prescriptions?
>>      It's not obvious to me...
>>
>>REPLY from Steven Mayer Mayers@xxxxxxxxxxxxxxxxxxxxx,; Dec29,1995
>        I am a 66 year old retired research pharmacologist with dx of PD in
>1992; moderate regression until, December, 1994, then increasing intractible
>dyskinasia , especially of lower back and most leg muscles. Sinemet (9x
>25/100 during day became less effective. I tried pergolide (Permax) last
>March but quit because of sedation, poor relief of PD symptoms. Started
>again abour 3 weeks ago with slowly increasing doses from 0.0.05 to 0.75
>mg/day in 3 divided administrations. Sinemet was reduced to 3x 25/100. This
>time sedation  and anxiety were not as bad. I do have longer "on" periods,
>but can't count on more than a few hours in which to be productive. Most
>terrible is "freezing" in public accompanied by intense urge for frequent
>urination.
>        At this point I feel its worth continuing the Permax.
>
>        "b.i.d." and "t.i.d." mean : twice a day and three times a day,
>respectively. Good luck.
>        Steven
>Steven E. Mayer, Ph.D.
>
>
>
Steven E. Mayer, Ph.D.